Dichloromethane → 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic hydrazide

HRID 1733019Notes

Reaction equation

HRID 1733019 reaction equation
C([O:3][C:4](=O)[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[C:16]([Cl:18])[CH:15]=[N:14]2)=[C:9]([Cl:19])[CH:8]=1)[CH3:6])C.O.[NH2:22][NH2:23].C(Cl)Cl>CN(C)C=O>[Cl:19][C:9]1[CH:8]=[C:7]([CH:5]([CH3:6])[C:4]([NH:22][NH2:23])=[O:3])[CH:12]=[CH:11][C:10]=1[N:13]1[CH:17]=[C:16]([Cl:18])[CH:15]=[N:14]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 24654Hydrazine hydrate (1:1)HCID 539945502-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester

Product 1

HCID 203034532-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic hydrazide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 3.13 g (10 mmoles) of 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester in 20 ml of dimethyl formamide there are added dropwise, at room temperature, 15 ml of hydrazine hydrate. Stirring is continued for a further 2 hours at room temperature, followed by pouring on to ice, extraction with methylene chloride, drying of the organic phase and concentration. 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic hydrazide is obtained.

Workup

  1. customdrying of the organic phase and concentration

Sources & evidence

ORD record
ord-af8a77639e9d47ea94cf177211d147b6
Source dataset
uspto-grants-1980_12
Patent number
US04239901

Reaction notes

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