Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 54250380 | HCID 54250380 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 20303480 | HCID 20303480 | — |
Reaction Steps
To 2.51 g (10 mmoles) of 4-(4-chloropyrazol-1-yl) phenylglyoxylic acid in 20 ml of 1,2-dimethoxyethane there are added 1.5 g (30 mmoles) of hydrazine hydrate and, after 15 minutes, 1.34 g of potassium hydroxide. Heating to 150° C. is effected for one hour, followed by pouring on to ice water, extraction with diethyl ether, acidification of the aqueous phase, extraction again with ether, concentration of the ethereal phase; 4-(4-chloropyrazol-1-yl) phenylacetic acid is obtained as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04239901 |
|---|
| Source dataset | uspto-grants-1980_12 |
|---|
| ORD ID | ord-708e4a9c36b44bb0a931c932dd3418c8 |
|---|
| Source note | uspto-grants-1980_12 |
|---|
