Diethyl Ether → HCID 20303480, compound

HRID 1733027Notes

Reaction equation

HRID 1733027 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13](=O)[C:14]([OH:16])=[O:15])=[CH:9][CH:8]=2)[CH:6]=1.O.NN.[OH-].[K+].C(OCC)C>COCCOC>[Cl:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[CH:8]=[CH:9][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:11][CH:12]=2)[CH:6]=1

Participants

6

Reactant 4

HCID 3283Diethyl Ether2×HCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 54250380HCID 54250380, compound

Product 1

HCID 20303480HCID 20303480, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
150 °C

Procedure

To 2.51 g (10 mmoles) of 4-(4-chloropyrazol-1-yl) phenylglyoxylic acid in 20 ml of 1,2-dimethoxyethane there are added 1.5 g (30 mmoles) of hydrazine hydrate and, after 15 minutes, 1.34 g of potassium hydroxide. Heating to 150° C. is effected for one hour, followed by pouring on to ice water, extraction with diethyl ether, acidification of the aqueous phase, extraction again with ether, concentration of the ethereal phase; 4-(4-chloropyrazol-1-yl) phenylacetic acid is obtained as oil.

Workup

  1. waitis effected for one hour

Sources & evidence

ORD record
ord-708e4a9c36b44bb0a931c932dd3418c8
Source dataset
uspto-grants-1980_12
Patent number
US04239901

Reaction notes

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