Water → HCID 20302326, compound

HRID 1733046Notes

Reaction equation

HRID 1733046 reaction equation
C([O:4][C:5]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)([CH3:9])[CH2:6][CH2:7][NH2:8])(=O)C.[OH-].[K+].O.C(Cl)(Cl)Cl>CO>[F:22][C:19]1[CH:18]=[CH:17][C:16]([C:13]2[CH:14]=[CH:15][C:10]([C:5]([OH:4])([CH3:9])[CH2:6][CH2:7][NH2:8])=[CH:11][CH:12]=2)=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6212ChloroformHCID 14797Potassium HydroxideHCID 20302923HCID 20302923, compound

Product 1

HCID 20302326HCID 20302326, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

30.1 g of 3-acetoxy-3-(4'-fluoro-4-biphenylyl)-1-butylamine [obtainable from 3-bromo-3-(4'-fluoro-4-biphenylyl)-1-butylamine and potassium acetate] are boiled for 2 hours with 20 g of KOH in 500 ml of methanol, and the mixture is worked up with water and chloroform to give 3-(4'-fluoro-4-biphenylyl)-3-hydroxybutylamine, m.p. 144°-146°.

Sources & evidence

ORD record
ord-4bb78df97928415c933e00a5298bc87c
Source dataset
uspto-grants-1980_12
Patent number
US04239759

Reaction notes

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