反应详情

After adding 29.4 g (0.21 mole) of benzoyl chloride, a mixture of 36 g (0.2 mole) of 2-amino-3-cyano-4-tert.-butyl-thiophene and 200 ml of toluene was boiled until the evolution of hydrogen chloride had ended (4 hours). Thereafter, the reaction mixture was filtered and the filtrate was concentrated on a rotary evaporator. The residue was recrystallized from methanol. 46.4 g of 2-benzoylamino-3-cyano-4-tert.-butyl-thiophene of melting point 130° C. were obtained in this manner.

1. custom(4 hours)
2. filtrationThereafter, the reaction mixture was filtered
3. concentrationthe filtrate was concentrated on a rotary evaporator
4. customThe residue was recrystallized from methanol