Acetyl chloride → HCID 20300372, compound

HRID 1733145Notes

Reaction equation

HRID 1733145 reaction equation
C(N(CC)CC)C.[NH2:8][C:9]1[S:10][CH:11]=[C:12]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:13]=1[C:14]([NH2:16])=[O:15].[C:21](Cl)(=[O:23])[CH3:22]>C1(C)C=CC=CC=1>[C:21]([NH:8][C:9]1[S:10][CH:11]=[C:12]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:13]=1[C:14]([NH2:16])=[O:15])(=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 16793423HCID 16793423, compound

Product 1

HCID 20300372HCID 20300372, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

21.2 g (0.21 mole) of triethylamine were first added to a suspension of 39.6 g (0.2 mole) of 2-amino-3-aminocarbonyl-4-tert.-butyl-thiophene in 300 ml of toluene, and 16.5 g (0.21 mole) of acetyl chloride were then added dropwise. After the exothermic reaction had ended, the mixture was worked up by filtering off the solid product and washing it with water. 38.6 g of 2-acetylamino-3-aminocarbonyl-4-tert.-butyl-thiophene of melting point 251° C. were obtained in this manner.

Workup

  1. additionwere then added dropwise
  2. customAfter the exothermic reaction
  3. filtrationby filtering off the solid product
  4. washwashing it with water

Sources & evidence

ORD record
ord-5f46feac3e124eb28d3a233b453c7af9
Source dataset
uspto-grants-1980_12
Patent number
US04240820

Reaction notes

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