Hydrochloric Acid → HCID 20300394, compound

HRID 1733164Notes

Reaction equation

HRID 1733164 reaction equation
Cl[C:2]1[C:10]2[N:9]=[N:8][N:7]([CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:17][O-:18].[Na+].Cl>CC1C=C(C)C=C(C)N=1.CO>[CH3:17][O:18][C:2]1[C:10]2[N:9]=[N:8][N:7]([CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 20300397HCID 20300397, compound

Product 1

HCID 20300394HCID 20300394, compoundYield 34%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 79532,4,6-TrimethylpyridineSolvent

Procedure

A slurry of 1.5 g of 4-chloro-1-cyclohexylbenzotriazole, 15 g of sodium methoxide, 10 g of cuprous iodide in 50 ml of 2,4,6-trimethyl pyridine (collidine) and 10 ml of methanol was heated at the reflux temperature for 26 hours. The reaction was cooled and poured into 150 ml of 10% hydrochloric acid. The product was extracted with ethyl ether and on evaporation of the solvent, 0.5 g of a oil was obtained which solidified on standing. The product has a melting point of 133°-134°.

Workup

  1. temperatureThe reaction was cooled
  2. extractionThe product was extracted with ethyl ether and on evaporation of the solvent

Sources & evidence

ORD record
ord-6d74604a15af44968ce27eac4c816125
Source dataset
uspto-grants-1980_12
Patent number
US04240822

Reaction notes

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