Hydrochloric Acid → pimonidazole

HRID 1733219Notes

Reaction equation

HRID 1733219 reaction equation
[N+:1]([C:4]1[N:5]([CH2:9][CH:10]([CH2:12][N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[OH:11])[CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2].[ClH:19]>C(O)C>[ClH:19].[N+:1]([C:4]1[N:5]([CH2:9][CH:10]([CH2:12][N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[OH:11])[CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 50981Pimonidazole

Product 1

HCID 104997pimonidazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.27 g of 2-nitro-α-(piperidino)methyl-1-imidazole-ethanol were dissolved in 25 ml of warm ethanol and treated with a small excess of anhydrous ethereal hydrogen chloride. The mixture was then allowed to cool and crystallize for several hours. There were obtained 1.4 g of 2-nitro-α-(piperidino)methyl-1-imidazole-ethanol hydrochloride in the form of a very pale cream colored microcrystalline solid identical with the product prepared as described in Example 3(b).

Workup

  1. temperatureto cool
  2. customcrystallize for several hours

Sources & evidence

ORD record
ord-0fd86e58550a476fae27ac20a3793d6d
Source dataset
uspto-grants-1980_12
Patent number
US04241060

Reaction notes

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