2-Chloroethyl isocyanate → HCID 54488192, compound

HRID 1733229Notes

Reaction equation

HRID 1733229 reaction equation
O=[CH:2][C@@H:3]([C@H:5]([C@H:7]([C@@H:9]([CH2:11][OH:12])[OH:10])[OH:8])[OH:6])[OH:4].[CH:13]1([CH2:16][NH2:17])[CH2:15][CH2:14]1.[Cl:18][CH2:19][CH2:20][N:21]=[C:22]=[O:23]>>[Cl:18][CH2:19][CH2:20][NH:21][C:22]([N:17]([CH2:16][CH:13]1[CH2:15][CH2:14]1)[CH:2]1[O:10][C@H:9]([CH2:11][OH:12])[C@H:7]([OH:8])[C@H:5]([OH:6])[C@H:3]1[OH:4])=[O:23]

Participants

4

Reactant 3

HCID 160352-Chloroethyl isocyanateHCID 75646CyclopropanemethanamineHCID 3037556(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanal

Product 1

HCID 54488192HCID 54488192, compoundYield 66.5%

Procedure

3.6 g of D-galactose, 2.2 g of cyclopropylmethylamine and 2.5 g of 2-chloroethyl isocyanate are treated in the same manner as described in Example 23-(1). 4.5 g of 1-(2-chloroethyl)-3-cyclopropylmethyl-3-(D-galactopyranosyl)urea are thereby obtained as colorless caramel.

Sources & evidence

ORD record
ord-9bd9e24f8d0c45ef9d637ef0e298f90f
Source dataset
uspto-grants-1980_12
Patent number
US04241052

Reaction notes

Loading…