2-Chloroethyl isocyanate → HCID 54488371, compound

HRID 1733231Notes

Reaction equation

HRID 1733231 reaction equation
O=[CH:2][C@@H:3]([C@H:5]([C@H:7]([C@@H:9]([CH2:11][OH:12])[OH:10])[OH:8])[OH:6])[OH:4].[CH:13]1([CH2:19][NH2:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.[Cl:21][CH2:22][CH2:23][N:24]=[C:25]=[O:26]>>[Cl:21][CH2:22][CH2:23][NH:24][C:25]([N:20]([CH2:19][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH:2]1[O:10][C@H:9]([CH2:11][OH:12])[C@H:7]([OH:8])[C@H:5]([OH:6])[C@H:3]1[OH:4])=[O:26]

Participants

4

Reactant 3

HCID 160352-Chloroethyl isocyanateHCID 76688CyclohexanemethylamineHCID 3037556(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanal

Product 1

HCID 54488371HCID 54488371, compoundYield 61.8%

Procedure

3.6 g of D-galactose, 4.5 g of cyclohexylmethylamine and 2.5 g of 2-chloroethyl isocyanate are treated in the same manner as described in Example 23-(1). 4.7 g of 1-(2-chloroethyl)-3-cyclohexylmethyl-3-(D-galactopyranosyl)urea are thereby obtained as colorless caramel.

Sources & evidence

ORD record
ord-8648e183cc9a4e1d847a3c184eb9d43d
Source dataset
uspto-grants-1980_12
Patent number
US04241052

Reaction notes

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