Triethylamine → HCID 20301130, compound

HRID 1733291Notes

Reaction equation

HRID 1733291 reaction equation
Cl[S:2][C:3]([CH3:7])([CH3:6])[C:4]#[N:5].[CH3:8][C:9]1[C:23]([CH3:24])=[CH:22][CH:21]=[CH:20][C:10]=1[O:11][CH:12]([C:15]1[NH:16][CH2:17][CH2:18][N:19]=1)[CH2:13][CH3:14].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:4]([C:3]([S:2][N:19]1[CH2:18][CH2:17][N:16]=[C:15]1[CH:12]([O:11][C:10]1[CH:20]=[CH:21][CH:22]=[C:23]([CH3:24])[C:9]=1[CH3:8])[CH2:13][CH3:14])([CH3:7])[CH3:6])#[N:5]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12577035HCID 12577035, compoundHCID 19889661HCID 19889661, compound

Product 1

HCID 20301130HCID 20301130, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

With continuous stirring and cooling, 4.1 g of α-(chlorothio)-isobutyronitrile are added dropwise at 0° to 10° C. to a solution of 6.97 g of 2-[1-(2,3-dimethylphenoxy)-propyl]-2-imidazoline of the formula ##STR4## and 4 g of triethylamine in 80 ml of toluene. The reaction mixture is stirred for 1 hour at room temperature, then the toluene phase is washed repeatedly with water and dried. The toluene is then evaporated off, affording 1-(2-cyano-prop-2-ylthio)-2-[1-(2,3-dimethylphenoxy)-propyl]-2-imidazoline of the formula ##STR5## in the form of a yellow viscous oil with a melting point of 58°-60° C. The following compounds of the formula I can be obtained by procedures analogous to the one described in this Example: ##STR6##

Workup

  1. temperaturecooling
  2. stirringThe reaction mixture is stirred for 1 hour at room temperature
  3. washthe toluene phase is washed repeatedly with water
  4. customdried
  5. customThe toluene is then evaporated off

Sources & evidence

ORD record
ord-101d9c26c1644426a92171d2e2d7bdcf
Source dataset
uspto-grants-1980_12
Patent number
US04241075

Reaction notes

Loading…