Methylamine → HCID 178472134, compound

HRID 1733297Notes

Reaction equation

HRID 1733297 reaction equation
[CH3:1][NH2:2].[ClH:3].[CH2:4]([O:6][C:7]([CH2:9][C:10](=[NH:14])OCC)=[O:8])[CH3:5]>C(O)C>[ClH:3].[CH3:1][NH:2][C:10](=[NH:14])[CH2:9][C:7]([O:6][CH2:4][CH3:5])=[O:8]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 75345Ethyl 3-ethoxy-3-iminopropionate hydrochloride

Product 1

HCID 178472134HCID 178472134, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 7.0 gm. (0.22 mole) of methylamine dissolved in 50 ml. of absolute ethanol at ice-bath temperature is added 41.4 gm. (0.207 mole) of ethyl ethoxycarbonylacetimidate hydrochloride. The reaction mixture is allowed to warm to room temperature and stirred for 5 hours. The solvent is removed and a mixture of acetone-ether is added to induce crystallization. 36.8 Gm. of crystalline product is collected as the hydrochloride salt.

Workup

  1. customThe solvent is removed
  2. additiona mixture of acetone-ether
  3. additionis added
  4. customcrystallization
  5. customof crystalline product is collected as the hydrochloride salt

Sources & evidence

ORD record
ord-0fba62a7b0c94750b4c5f12d3f6ece90
Source dataset
uspto-grants-1980_12
Patent number
US04241072

Reaction notes

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