反应详情

A 1.2 g. portion of β-amino-3-thiopheneacrylonitrile is added to 10 ml. of 1 N hydrochloric acid. A 40 ml. portion of methanol is added and the mixture is stirred for 3 hours. The mixture is evaporated in vacuo to a residue which is dissolved in 35 ml. of hot methanol and treated with charcoal. After cooling, petroleum ether is added, the mixture is filtered and the solid collected is discarded. The filtrate is allowed to evaporate and the residue is dissolved in 35 ml. of hot isopropanol and isoluble material filtered and discarded The filtrate is cooled and the solid is collected giving the desired product as white plates, m.p. 87°-88° C.

1. customThe mixture is evaporated in vacuo to a residue which
2. dissolutionis dissolved in 35 ml
3. additionof hot methanol and treated with charcoal
4. temperatureAfter cooling
5. additionpetroleum ether is added
6. filtrationthe mixture is filtered
7. customthe solid collected
8. customto evaporate
9. dissolutionthe residue is dissolved in 35 ml
10. filtrationof hot isopropanol and isoluble material filtered
11. temperatureis cooled
12. customthe solid is collected