反应详情

A mixture of 2,4,5-trimethoxybenzaldehyde (9.8 g; 0.05 mole), 3-n-butylhydantoin (7.8 g: 0.05 mole) and ethanolamine (4.6 g; 0.075 mole) in water/ethanol (50 ml/30 ml) was stirred and boiled under reflux for 3 hours. The cloudy solution was cooled in the refrigerator and the resultant yellow solid filtered off, washed with water, sucked dry and recrystallised from ethanol to give the title compound (14.5 g; 87%) m.p. 170° C.

1. temperatureunder reflux for 3 hours
2. temperatureThe cloudy solution was cooled in the refrigerator
3. filtrationthe resultant yellow solid filtered off
4. washwashed with water
5. customsucked dry
6. customrecrystallised from ethanol