HCID 178508524, compound → HCID 178460095, compound

HRID 1733360Notes

Reaction equation

HRID 1733360 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>C(OC(=O)CC)(=O)CC>[NH2:9][C:5]1[C:6]([OH:8])=[N:7][C:2]([NH:1][C:6](=[O:8])[CH2:5][CH3:4])=[N:3][CH:4]=1

Participants

3

Reactant 1

HCID 178508524HCID 178508524, compound

Product 1

HCID 178460095HCID 178460095, compound

Reagents, catalysts & solvents 1

HCID 31263Propionic anhydrideSolvent

Procedure

7.8 gm (0.055 mol) of 2-amino-4-hydroxy-5-nitropyrimidine are heated for 4 hours to 140° C. in 50 ml of propionic acid anhydride. The mixture is cooled and the precipitated product is extracted and washed with ether. The compound is suspended in 200 ml of dimethyl formamide and hydrogenated at room temperature and normal pressure with 1 gm of Pd/C as catalyst.

Workup

  1. temperatureThe mixture is cooled
  2. extractionthe precipitated product is extracted
  3. washwashed with ether
  4. customis suspended in 200 ml of dimethyl formamide and hydrogenated at room temperature

Sources & evidence

ORD record
ord-6780981f04054bb19670ac98233bcbaf
Source dataset
uspto-grants-1980_12
Patent number
US04241056

Reaction notes

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