Dimethyl sulfite → HCID 178502519, compound

HRID 1733371Notes

Reaction equation

HRID 1733371 reaction equation
[NH:1]=[C:2]1[CH:7]=[C:6]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:5]=[C:4]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:3]1[NH:23][C:24]([NH:26][C:27]([O:29][CH3:30])=[O:28])=[S:25].[OH-].[Ca+2].[OH-].S(OC)(O[CH3:37])=O>CN(C)C=O.O>[NH:1]=[C:2]1[CH:7]=[C:6]([C:8](=[O:15])[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:5]=[C:4]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:3]1[NH:23][C:24](=[N:26][C:27]([O:29][CH3:30])=[O:28])[S:25][CH3:37]

Participants

6

Reactant 3

HCID 69223Dimethyl sulfiteHCID 6093208Calcium HydroxideHCID 131711982HCID 131711982, compound

Product 1

HCID 178502519HCID 178502519, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
30 °C

Procedure

To a solution of 1-iminophenylmethyl-2-(3-carbomethoxythioureido)-5-benzoylbenzene (4.33 g.; 0.01 mol) in dimethylformamide (50 ml.) and water (5 ml.) there is added calcium hydroxide (0.74 g.; 0.01 mol). The mixture is stirred at 30° C. for 2 hours and to it there is added dimethyl sulfite (1.1 g.; 0.01 mol). The mixture is stirred at room temperature for 3 hours and the precipitate collected and dried to afford 1-iminophenylmethyl-2-(3-carbomethoxy-S-methylisothioureido)-5-benzoylbenzene.

Workup

  1. stirringThe mixture is stirred at room temperature for 3 hours
  2. customthe precipitate collected
  3. customdried

Sources & evidence

ORD record
ord-e1ab253a492e4224852901ba2db2ad9f
Source dataset
uspto-grants-1980_12
Patent number
US04241079

Reaction notes

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