3-(Trifluoromethyl)aniline → HCID 54312843, compound

HRID 1733436Notes

Reaction equation

HRID 1733436 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].[O:12]=[P:13](Cl)([Cl:15])[Cl:14]>>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:4]=[C:5]([NH:6][P:13]([Cl:15])([Cl:14])=[O:12])[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 24813Phosphorus oxychloride

Product 1

HCID 54312843HCID 54312843, compound

Procedure

To a solution of 60 g (0.37 m) of 3-trifluoromethylaniline and 300 ml of POCl3 was heated at reflux for 3 hours. The excess POCl3 was removed by vacuum distillation to yield 102 g of a red-brown oil.

Workup

  1. temperatureat reflux for 3 hours
  2. customThe excess POCl3 was removed by vacuum distillation

Sources & evidence

ORD record
ord-68c7888869484d1aae5e84508959ff05
Source dataset
uspto-grants-1980_12
Patent number
US04242325

Reaction notes

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