Piperazine → HCID 12841593, compound

HRID 1733464Notes

Reaction equation

HRID 1733464 reaction equation
[Cl:1]C1[N:6]2[CH:7]=[CH:8][N:9]=[C:10](Cl)[C:5]2=NC=1.Br[C:13]1[C:14]2[N:15]([C:19]([Cl:22])=[CH:20][N:21]=2)[CH:16]=[CH:17][N:18]=1.N1CCNCC1>C(#N)C>[ClH:1].[Cl:22][C:19]1[N:15]2[CH:16]=[CH:17][N:18]=[C:13]([N:6]3[CH2:7][CH2:8][NH:9][CH2:10][CH2:5]3)[C:14]2=[N:21][CH:20]=1

Participants

5

Reactant 3

HCID 4837PiperazineHCID 12841587HCID 12841587, compoundHCID 202996378-Bromo-3-chloroimidazo[1,2-a]pyrazine

Product 1

HCID 12841593HCID 12841593, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of the mixture of 3,8-dichloroimidazo[1,2-a]pyrazine and 8-bromo-3-chloroimidazo[1,2-a]pyrazine obtained above in 25 ml of acetonitrile is added an excess amount of piperazine (5 g). After refluxing and isolation in essentially the same manner as Example 1, Step B, 3-chloro-8-(1-piperazinyl)-imidazo[1,2-a]pyrazine hydrochloride salt is obtained with m.p. >300° C. dec.

Workup

  1. temperatureAfter refluxing

Sources & evidence

ORD record
ord-9399a5c83c834b4dbc2ba942bd37d36b
Source dataset
uspto-grants-1980_12
Patent number
US04242344

Reaction notes

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