HCID 15149679, compound → 8-chloro-3-methylImidazo[1,2-a]pyrazine

HRID 1733466Notes

Reaction equation

HRID 1733466 reaction equation
[CH3:1][C:2]([CH2:4][NH:5][C:6]1[C:11]([Cl:12])=[N:10][CH:9]=[CH:8][N:7]=1)=O>FC(F)(F)C(OC(=O)C(F)(F)F)=O>[Cl:12][C:11]1[C:6]2[N:7]([C:2]([CH3:1])=[CH:4][N:5]=2)[CH:8]=[CH:9][N:10]=1

Participants

3

Reactant 1

HCID 15149679HCID 15149679, compound

Product 1

HCID 151496808-chloro-3-methylImidazo[1,2-a]pyrazine

Reagents, catalysts & solvents 1

HCID 9845Trifluoroacetic anhydrideSolvent

Procedure

A 2.67 g (0.01 mol) sample of 3-chloro-2-(2-oxo-1-propanamino)pyrazine is dissolved in 10 ml of trifluoroacetic anhydride under nitrogen and after the exothermic reaction subsides, the mixture is concentrated under vacuum. The residue is partitioned between chloroform and aqueous sodium bicarbonate, and the chloroform extract dried over sodium sulfate, filtered and concentrated under vacuum to give the solid 8-chloro-3-methylimidazo[1,2-a]pyrazine.

Workup

  1. customafter the exothermic reaction subsides
  2. concentrationthe mixture is concentrated under vacuum
  3. customThe residue is partitioned between chloroform and aqueous sodium bicarbonate
  4. extractionthe chloroform extract
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-3ac6f09d9ada4400a2f895e53bb236bc
Source dataset
uspto-grants-1980_12
Patent number
US04242344

Reaction notes

Loading…