1,2,4-Oxadiazol-3-amine, 5-((2,6-dichlorophenyl)methyl)- → HCID 54050783, compound

HRID 1733479Notes

Reaction equation

HRID 1733479 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([CH2:7][C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:15])[O:4][N:3]=1.[CH:16]([O-])([O-])[O:17][CH2:18][CH3:19]>>[CH2:18]([O:17][CH:16]=[N:1][C:2]1[N:6]=[C:5]([CH2:7][C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:15])[O:4][N:3]=1)[CH3:19]

Participants

3

Reactant 2

HCID 27431271,2,4-Oxadiazol-3-amine, 5-((2,6-dichlorophenyl)methyl)-HCID 53630039Ethylorthoformate2×

Product 1

HCID 54050783HCID 54050783, compound

Procedure

1 g of 3-amino-5-(2,6-dichlorobenzyl)-1,2,4-oxadiazole is heated in air at 150° C. for 3 hours with a few ml of ethyl orthoformate in an amount which is just sufficient to ensure slight agitation. The excess ethyl orthoformate is driven off under reduced pressure. The residue is crystallised from ether.

Workup

  1. customThe residue is crystallised from ether

Sources & evidence

ORD record
ord-614384af29274804a55aacaf18eba29c
Source dataset
uspto-grants-1980_12
Patent number
US04242352

Reaction notes

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