Hydrochloric Acid → HCID 20437367, compound

HRID 1733533Notes

Reaction equation

HRID 1733533 reaction equation
FC(F)(F)C([N:5]([C:22]1[CH:41]=[CH:40][C:25]([C:26]([NH:28][C:29]2[CH:39]=[CH:38][C:32]([C:33]([O:35]CC)=[O:34])=[CH:31][CH:30]=2)=[O:27])=[CH:24][CH:23]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=O.C(O)C.[OH-].[Na+].Cl>O>[CH2:6]([NH:5][C:22]1[CH:41]=[CH:40][C:25]([C:26]([NH:28][C:29]2[CH:39]=[CH:38][C:32]([C:33]([OH:35])=[O:34])=[CH:31][CH:30]=2)=[O:27])=[CH:24][CH:23]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 20437363HCID 20437363, compound

Product 1

HCID 20437367HCID 20437367, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 3.62 g. of ethyl p-[p-(2,2,2-trifluoro-N-hexadecylacetamido)benzamido]benzoate in 72 ml. of ethanol was added a solution of 1.44 g. of sodium hydroxide in 18 ml. of water and the resulting mixture was heated under reflux for 30 min. The mixture was allowed to cool, acidified with dilute hydrochloric acid, and filtered. The white solid was recrystallized from acetonitrile.

Workup

  1. temperatureunder reflux for 30 min
  2. temperatureto cool
  3. filtrationfiltered
  4. customThe white solid was recrystallized from acetonitrile

Sources & evidence

ORD record
ord-63df9d877b3e44fbbb320869d91e4b68
Source dataset
uspto-grants-1980_12
Patent number
US04242273

Reaction notes

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