Tetrahydrofuran → HCID 86737120, compound

HRID 1733540Notes

Reaction equation

HRID 1733540 reaction equation
[CH2:1]([OH:26])[CH2:2][CH2:3][CH2:4][C:5]#[C:6][C:7]#[C:8][CH2:9][CH2:10][C:11]#[C:12][C:13]#[C:14][CH2:15][CH2:16][C:17]#[C:18][C:19]#[C:20][CH2:21][CH2:22][CH2:23][CH2:24][OH:25].[CH2:27]([N:36]=[C:37]=[O:38])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][N:33]=[C:34]=[O:35].[O:39]1CC[CH2:41][CH2:40]1>>[NH:33]([CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][NH:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])[C:34]([O:25][CH2:24][CH3:23])=[O:35].[CH2:24]([OH:25])[CH2:23][CH2:22][CH2:21][C:20]#[C:19][C:18]#[C:17][CH2:16][CH2:15][C:14]#[C:13][C:12]#[C:11][CH2:10][CH2:9][C:8]#[C:7][C:6]#[C:5][CH2:4][CH2:3][CH2:2][CH2:1][OH:26]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 13192Hexamethylene diisocyanateHCID 20165401HCID 20165401, compound

Product 1

HCID 86737120HCID 86737120, compound

Procedure

In a reaction vessel 1.73 parts CF4 diol produced from Example 23, was reacted with 0.84 parts hexamethylene diisocyanate in 70 parts of tetrahydrofuran at room temperature for 4 hours in the presence of a catalytic amount of DBTE and TEA. The product was precipitated with heptane and filtered. After washing several times with heptane, it was vacuum dried to yield 1.7 parts of XXV, a light tan fluffy material, melting point, 161.3° to 165.1° C.

Workup

  1. customThe product was precipitated with heptane
  2. filtrationfiltered
  3. washAfter washing several times with heptane, it
  4. customdried

Sources & evidence

ORD record
ord-c514f4f23a0640fd813c685f7eb407f3
Source dataset
uspto-grants-1980_12
Patent number
US04242440

Reaction notes

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