反应详情

To a solution of 37.6 g. of sodium methoxide in 650 ml. of methanol is added 29.24 g. of cyanoacetamide followed by 26.1 g. of 2-(4-chlorophenyl)-3-(dimethylamino)-2-propenal. The resulting solution is heated at reflux temperature for 16 hours to separate a yellow solid. Then 50 ml. of glacial acetic acid is added and the mixture is diluted with water, causing a new yellow solid to separate. This solid is collected by filtration and is washed with water to give 60.5 g. of the product of the Example m.p. 285°-290° C.

1. temperatureThe resulting solution is heated
2. temperatureat reflux temperature for 16 hours
3. customto separate a yellow solid
4. additionof glacial acetic acid is added
5. additionthe mixture is diluted with water
6. customto separate
7. filtrationThis solid is collected by filtration
8. washis washed with water
9. customto give 60.5 g