反应详情

A mixture of 22.27 g. of 5-(4-chlorophenyl)-2(1H)-pyridinone and 100 ml. of phosphorus oxychloride is refluxed for 16 hours, chilled and poured onto cracked ice. The solid formed is collected by filtration and then is dissolved in chloroform. The chloroform solution is washed with water and with saturated sodium bicarbonate and then is dried over magnesium sulfate. The solvent is evaporated at reduced pressure to yield 21.1 g. of the product of the Example as a gray solid, m.p. 113°-115° C.

1. additionA mixture of 22.27 g
2. temperaturechilled
3. additionpoured
4. customThe solid formed
5. filtrationis collected by filtration
6. dissolutionis dissolved in chloroform
7. washThe chloroform solution is washed with water and with saturated sodium bicarbonate
8. dry with materialis dried over magnesium sulfate
9. customThe solvent is evaporated at reduced pressure
10. customto yield 21.1 g