Acetohydrazide → 3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-a]pyridine

HRID 1733583Notes

Reaction equation

HRID 1733583 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:4][N:3]=1.[C:18]([NH:21][NH2:22])(=O)[CH3:19]>C(O)CCC>[CH3:19][C:18]1[N:3]2[CH:4]=[C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=3)[CH:6]=[CH:7][C:2]2=[N:22][N:21]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 15192309HCID 15192309, compound

Product 1

HCID 202963343-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-a]pyridine

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 2 g. of 2-chloro-5-[3-(trifluoromethyl)phenyl]pyridine and two equivalents of acetylhydrazine in n-butanol is heated at reflux for 48 hours to give the product of the Example as crystals, m.p. 185°-187° C.

Workup

  1. additionA mixture of 2 g
  2. temperatureat reflux for 48 hours
  3. customto give the product of the Example as crystals, m.p. 185°-187° C.

Sources & evidence

ORD record
ord-a119ef3f73d248b681e2f96e273e06de
Source dataset
uspto-grants-1980_12
Patent number
US04242515

Reaction notes

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