HCID 43218479, compound → HCID 20300160, compound

HRID 1733600Notes

Reaction equation

HRID 1733600 reaction equation
CO[C:3](=[O:16])[CH2:4][CH2:5][S:6][CH2:7][C:8](=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O(C)[Na].CO>>[OH:16][CH:3]1[CH:4]=[CH:5][S:6][CH:7]1[C:8](=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 43218479HCID 43218479, compoundHCID 178501943HCID 178501943, compound

Product 1

HCID 20300160HCID 20300160, compoundYield 90%

Conditions

Temperature
0 °C

Procedure

23.8 parts of 3-(benzoylmethylthio)-propionic acid methyl ester are added in the course of 30 minutes to 36 parts of a 30 percent strength by weight NaOCH3 /MeOH solution which has been cooled to 0° C., and the mixture is stirred for 2 hours at from 0° to 10° C. The end product is isolated from the reaction mixture by the method described in Example 14(b). 18.5 parts (90% of theory) of 3-hydroxy-2-benzoyldihydrothiophene of boiling point 137°-140° C./0.16-0.08 mbar are obtained.

Workup

  1. customThe end product is isolated from the reaction mixture by the method

Sources & evidence

ORD record
ord-57520a8b14f74a42963d9f0dc8347447
Source dataset
uspto-grants-1980_12
Patent number
US04242518

Reaction notes

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