反应详情

Tetrazole-1-acetic acid (0.64 g), benzyl alcohol (0.65 g) and pyridine (0.80 ml) are dissolved in dry cyanomethane (10 ml) and thereto is added 1-(p-chlorobenzenesulfonyloxy)-6-chloro-1,2,3-benzotriazole (1.72 g) under ice-cooling. After allowing to stand overnight, to the mixture are added water and ethyl acetate. The ethyl acetate layer is washed, dried and concentrated. The precipitated crystals are washed well with ether-petroleum ether to give benzyl tetrazole-1-acetate (815 mg), melting point: 69°-72° C.

1. temperaturecooling
2. washThe ethyl acetate layer is washed
3. customdried
4. concentrationconcentrated
5. washThe precipitated crystals are washed well with ether-petroleum ether