2-Mercaptoethanol → HCID 53703915, compound

HRID 1733727Notes

Reaction equation

HRID 1733727 reaction equation
Cl[CH:2]([CH3:19])[C:3](=[O:18])[C:4](=[N:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[SH:20][CH2:21][CH2:22][OH:23].C(N(CC)CC)C>C(Cl)(Cl)Cl>[OH:23][CH2:22][CH2:21][S:20][CH:2]([CH3:19])[C:3](=[O:18])[C:4](=[N:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Participants

5

Reactant 3

HCID 15672-MercaptoethanolHCID 8471TriethylamineHCID 53662430HCID 53662430, compound

Product 1

HCID 53703915HCID 53703915, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Ethyl 4-chloro-3-oxo-2-n-hexyloxyiminovalerate (255.0 g.), 2-mercaptoethanol (86.1 g.), triethylamine (11.13 g.) and chloroform (2.8 l.) were treated in a similar manner to that of Example I-(i) and stirred at room temperature for 3.5 hours. The resultant solution was treated in a similar manner to that of Example I-(i) to give ethyl 4-(2-hydroxyethylthio)-3-oxo-2-n-hexyloxyiminovalerate (290.5 g.).

Sources & evidence

ORD record
ord-48362ec9afdd4fb4b223e876c8525d52
Source dataset
uspto-grants-1980_12
Patent number
US04242510

Reaction notes

Loading…