Hydrochloric Acid → HCID 15818098, compound

HRID 1733821Notes

Reaction equation

HRID 1733821 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1)[CH2:6][P:7](=[O:14])([O:11]CC)[O:8]CC.Cl>C(O)C>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([C:18]([F:21])([F:19])[F:20])[CH:17]=1)[CH2:6][P:7](=[O:8])([OH:11])[OH:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15818097Diethyl {[3,5-bis(trifluoromethyl)phenyl]methyl}phosphonate

Product 1

HCID 15818098HCID 15818098, compoundYield 49.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diethyl 3,5-bis(trifluoromethyl)benzylphosphonate (1.0 g, 2.7 mmol)in 15 mL of cone hydrochloric acid and 0.5 mL of ethanol was heated at reflux for 72 hours. The mixture was evaporated to an oily residue which crystallized upon standing to give 0.41 g of the product (49% yield) the as a white solid: mp. 206°-208° C.; D.C.I.M.S. [MH+, 309].

Workup

  1. temperatureat reflux for 72 hours
  2. customThe mixture was evaporated to an oily residue which
  3. customcrystallized

Sources & evidence

ORD record
ord-ab1775352ed14f9eb7fa44fb14b1e40f
Source dataset
uspto-grants-1996_07
Patent number
US05532226

Reaction notes

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