Ethoxalyl chloride → HCID 19438794, compound

HRID 1733878Notes

Reaction equation

HRID 1733878 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([C:11]([F:14])([F:13])[F:12])=[C:4]([N:15]2[CH:19]=[CH:18][N:17]=[C:16]2[CH3:20])[CH:3]=1.[C:21](Cl)([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:22]>N1C=CC=CC=1>[C:21]([NH:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([C:11]([F:12])([F:13])[F:14])=[C:4]([N:15]2[CH:19]=[CH:18][N:17]=[C:16]2[CH3:20])[CH:3]=1)([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:22]

Participants

4

Reactant 2

HCID 20884Ethoxalyl chlorideHCID 19438759HCID 19438759, compound

Product 1

HCID 19438794HCID 19438794, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 14.5 g (~50.7 mmol) of 4-amino-2-(2-methyl-1H-imidazol-1-yl)-5-nitrobenzotrifluoride in 200 ml dry pyridine was added dropwise 11,3 ml (~102 mmol) ethoxalyl chloride, and stirring was continued overnight at room temperature. The reaction mixture was filtered and the filtrate was evaporated to give the title compound as a crude oil (19 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-178e26316b8f4820808648cac9bee9a7
Source dataset
uspto-grants-1996_07
Patent number
US05532236

Reaction notes

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