HCID 19438768, compound → HCID 19438762, compound

HRID 1733881Notes

Reaction equation

HRID 1733881 reaction equation
C([O:8][N:9]1[C:18]2[C:13](=[CH:14][C:15]([N:23]3[CH:27]=[CH:26][N:25]=[C:24]3[CH3:28])=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=2)[N:12]=[C:11]([NH:29][NH:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[C:10]1=[O:36])C1C=CC=CC=1>C(O)C.CN(C)C=O.[Pd]>[CH2:34]([O:33][C:31]([NH:30][NH:29][C:11]1[C:10](=[O:36])[N:9]([OH:8])[C:18]2[C:13]([N:12]=1)=[CH:14][C:15]([N:23]1[CH:27]=[CH:26][N:25]=[C:24]1[CH3:28])=[C:16]([C:19]([F:20])([F:21])[F:22])[CH:17]=2)=[O:32])[CH3:35]

Participants

5

Reactant 1

HCID 19438768HCID 19438768, compound

Product 1

HCID 19438762HCID 19438762, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of 1.4 g (~2.8 mmol) 1-benzyloxy-3-(2-ethoxycarbonylhydrazino)-6-(2-methyl-1H-imidazol-1-yl)-7-trifluoromethylquinoxalin-2(1H)-one in a mixture of 100 ml ethanol and 50 ml N,N-dimethylformamide was hydrogenated at atmospheric pressure by using 0.15 g 5% Pd-C as a catalyst. The catalyst was removed by filtration, and the filtrate was evaporated in vacuo to give the title compound as a crude product (1 g).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-c916a1cc9a74497fb607bd01389623a9
Source dataset
uspto-grants-1996_07
Patent number
US05532236

Reaction notes

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