Hydrazine hydrate (1:1) → HCID 19438751, compound

HRID 1733892Notes

Reaction equation

HRID 1733892 reaction equation
O.[NH2:2][NH2:3].[CH2:4]([O:11][N:12]1[C:21]2[C:16](=[CH:17][C:18]([N:26]3[CH:30]=[CH:29][N:28]=[CH:27]3)=[C:19]([C:22]([F:25])([F:24])[F:23])[CH:20]=2)[N:15]=[C:14](Cl)[C:13]1=[O:32])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>ClCCl>[CH2:4]([O:11][N:12]1[C:21]2[C:16](=[CH:17][C:18]([N:26]3[CH:30]=[CH:29][N:28]=[CH:27]3)=[C:19]([C:22]([F:25])([F:24])[F:23])[CH:20]=2)[N:15]=[C:14]([NH:2][NH2:3])[C:13]1=[O:32])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19438761HCID 19438761, compound

Product 1

HCID 19438751HCID 19438751, compoundYield 90.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

Hydrazine hydrate (2.7 ml, 55 mmol) was added to a solution of 5.9 g (14 mmol) of 1-benzyloxy-3-chloro-6-(1H-imidazol-1-yl)-7-trifluoromethylquinoxalin-2(1H)-one in 100 ml of dichloromethane with stirring at 0° C. After 1 h the mixture was evaporated to dryness and the residue was triturated with water and dried to give 5.3 g (90%) of crude title compound.

Workup

  1. customAfter 1 h the mixture was evaporated to dryness
  2. customthe residue was triturated with water
  3. customdried

Sources & evidence

ORD record
ord-47a63b894da147a1a8246fe9a427da25
Source dataset
uspto-grants-1996_07
Patent number
US05532236

Reaction notes

Loading…