Sodium Hydroxide → HCID 19438754, compound

HRID 1733894Notes

Reaction equation

HRID 1733894 reaction equation
C([O:8][N:9]1[C:18]2[C:13](=[CH:14][C:15]([N:23]3[CH:27]=[CH:26][N:25]=[CH:24]3)=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=2)[N:12]2[C:28](=[S:31])[NH:29][N:30]=[C:11]2[C:10]1=[O:32])C1C=CC=CC=1.[OH-].[Na+]>S(=O)(=O)(O)O>[OH:8][N:9]1[C:18]2[C:13](=[CH:14][C:15]([N:23]3[CH:27]=[CH:26][N:25]=[CH:24]3)=[C:16]([C:19]([F:20])([F:21])[F:22])[CH:17]=2)[N:12]2[C:28](=[S:31])[NH:29][N:30]=[C:11]2[C:10]1=[O:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19438780HCID 19438780, compound

Product 1

HCID 19438754HCID 19438754, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A solution of 1.38 g (3 mmol) of 5-benzyloxy-8-(1H-imidazol-1-yl)-1-thioxo-7-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one in 20 ml of conc. sulfuric acid was stirred at room temperature for 20 min., and poured into 200 ml of ice-water. The stirred mixture was adjusted to pH 5-6 by cautious addition of solid sodium hydroxide at 0° C. Extraction with ethyl acetate (5×100 ml) gave 270 mg (25%) of the title compound.

Workup

  1. extractionExtraction with ethyl acetate (5×100 ml)

Sources & evidence

ORD record
ord-327e0a835d8c4b02b2d81ade2705110c
Source dataset
uspto-grants-1996_07
Patent number
US05532236

Reaction notes

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