Sodium Hydroxide → HCID 19438754, compound

Participants

Reaction Steps

A solution of 1.38 g (3 mmol) of 5-benzyloxy-8-(1H-imidazol-1-yl)-1-thioxo-7-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one in 20 ml of conc. sulfuric acid was stirred at room temperature for 20 min., and poured into 200 ml of ice-water. The stirred mixture was adjusted to pH 5-6 by cautious addition of solid sodium hydroxide at 0° C. Extraction with ethyl acetate (5×100 ml) gave 270 mg (25%) of the title compound.

Provenance & Evidence