Triphenylphosphine → HCID 19438792, compound

HRID 1733895Notes

Reaction equation

HRID 1733895 reaction equation
O[N:2]1[C:11]2[C:6](=[CH:7][C:8]([N:16]3[CH:20]=[CH:19][N:18]=[CH:17]3)=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[N:5]2[C:21](=[S:24])[NH:22][N:23]=[C:4]2[C:3]1=[O:25].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[N:16]1([C:8]2[CH:7]=[C:6]3[C:11]([NH:2][C:3](=[O:25])[C:4]4[N:5]3[C:21](=[S:24])[NH:22][N:23]=4)=[CH:10][C:9]=2[C:12]([F:14])([F:15])[F:13])[CH:20]=[CH:19][N:18]=[CH:17]1

Participants

3

Reactant 2

HCID 11776TriphenylphosphineHCID 19438754HCID 19438754, compound

Product 1

HCID 19438792HCID 19438792, compoundYield 40%

Procedure

A solution of 250 mg (0.67 mmol) of 5-hydroxy-8-(1H-imidazol-1-yl)-1-thioxo-7-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one and 360 mg (1.37 mmol) of triphenylphosphine was stirred at 140° C. for 20 h. The solution was evaporated to dryness, and the solid residue was triturated with small portions of cold dichloromethane to give the crude product. Recrystallization from ethanol gave 90 mg (40%) of pure title compound. M.p.>300° C.

Workup

  1. customThe solution was evaporated to dryness
  2. customthe solid residue was triturated with small portions of cold dichloromethane
  3. customto give the crude product
  4. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-6ecf169ce06348b48239a8ae7af853d4
Source dataset
uspto-grants-1996_07
Patent number
US05532236

Reaction notes

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