Pyridinium chloride → HCID 19438824, compound

HRID 1733917Notes

Reaction equation

HRID 1733917 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:23]=[C:24]3[C:29](=[CH:30][CH:31]=2)[O:28][CH2:27][CH2:26][CH2:25]3)[CH2:18][CH2:17]1.Cl.N1C=CC=CC=1>N1C=CC=CC=1>[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:17][CH2:18][N:19]([C:22]2[CH:23]=[C:24]3[C:29](=[CH:30][CH:31]=2)[O:28][CH2:27][CH2:26][CH2:25]3)[CH2:20][CH2:21]1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 19438846HCID 19438846, compound

Product 1

HCID 19438824HCID 19438824, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 2.1 g of 1-[4-(5-methoxyindol-3-yl)butyl]-4-(chroman-6-yl)piperazine [can be prepared according to Example 1], 1.8 g of pyridine hydrochloride and 50 ml of pyridine is boiled for 3 hours. It is cooled and evaporated, and the residue is worked up in the customary manner and gives 1-[4-(5-hydroxyindol-3-yl)-butyl]-4-(chroman-6-yl)piperazine, m.p. 220°-222°.

Workup

  1. temperatureIt is cooled
  2. customevaporated

Sources & evidence

ORD record
ord-1562ee5110704344812232473fc29538
Source dataset
uspto-grants-1996_07
Patent number
US05532241

Reaction notes

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