Trifluoroacetic acid → HCID 19439146, compound

HRID 1733933Notes

Reaction equation

HRID 1733933 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH:12]([CH2:14][N:15]3[CH2:20][CH2:19][CH:18]([C:21]([O-:23])=[O:22])[CH2:17][CH2:16]3)[O:11][C:10]2=[O:24])=[CH:5][CH:4]=1)#[N:2].FC(F)(F)C(O)=O>ClCCl>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH:12]([CH2:14][N:15]3[CH2:20][CH2:19][CH:18]([C:21]([OH:23])=[O:22])[CH2:17][CH2:16]3)[O:11][C:10]2=[O:24])=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 19439145HCID 19439145, compound

Product 1

HCID 19439146HCID 19439146, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1 g of tert-butyl (1-(3-(4-cyanophenyl)-2-oxo-5-oxazolidinylmethyl)piperidine-4-carboxylate is dissolved in 12 ml of dichloromethane, and 12 ml of trifluoroacetic acid are then added; the mixture is left to stand for 5 min., concentrated by evaporation and worked up in the customary manner; 1-(3-(4-cyanophenyl)-2-oxo-5-oxazolidinylmethyl)piperidine-4-carboxylic acid, FAB 330, is obtained.

Workup

  1. waitthe mixture is left
  2. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-22fb3bae2b484897b53fd08cd140f334
Source dataset
uspto-grants-1996_07
Patent number
US05532255

Reaction notes

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