反应详情

6-Amino-5-bromopyridine-3-carboxylic acid (10 g, 50 mmol) is dissolved in saturated methanolic HCl (100 ml) and refluxed for 24 hours. The solvent, methanol, is re-moved under reduced pressure and the residue is dissolved in ice cold water. The aqueous solution is neutralized with 0.1N NaOH and the solid which separates is filtered; washed well with water and air dried to yield 10 g of product as a solid: mass spectrum 231 (M+).

1. temperaturerefluxed for 24 hours
2. dissolutionthe residue is dissolved in ice cold water
3. filtrationthe solid which separates is filtered
4. washwashed well with water and air
5. customdried