反应详情

To a slurry of 0.51 g of 6-[(dimethylamino)methylene]-6,7,8,9-tetrahydro-9-(4-nitrobenzoyl)-5H-pyrido[2,3-b]azepin-5-one in 17 ml of methanol under argon is added 0.14 g of hydrazine hydrate. The mixture is stirred overnight and the solvent removed under vacuum. The residue is dissolved in hot chloroform-methanol (95:5) and filtered through silica gel and washed filter pad with chloroform-methanol (95: 5). The filtrate is concentrated to dryness to give 0.48 g of yellow solid.

1. customthe solvent removed under vacuum
2. dissolutionThe residue is dissolved in hot chloroform-methanol (95:5)
3. filtrationfiltered through silica gel
4. washwashed
5. filtrationfilter pad with chloroform-methanol (95: 5)
6. concentrationThe filtrate is concentrated to dryness