Triethylamine → HCID 19699138, compound

HRID 1733997Notes

Reaction equation

HRID 1733997 reaction equation
[NH:1]1[C:5]2[C:6]3[S:13][CH:12]=[CH:11][C:7]=3[NH:8][CH2:9][CH2:10][C:4]=2[CH:3]=[N:2]1.C(N(CC)CC)C.[F:21][C:22]1[CH:23]=[CH:24][C:25]([CH3:40])=[C:26]([CH:39]=1)[C:27]([NH:29][C:30]1[N:35]=[CH:34][C:33]([C:36](Cl)=[O:37])=[CH:32][CH:31]=1)=[O:28].[OH-].[Na+]>ClCCl>[NH:1]1[C:5]2[C:6]3[S:13][CH:12]=[CH:11][C:7]=3[N:8]([C:36]([C:33]3[CH:32]=[CH:31][C:30]([NH:29][C:27](=[O:28])[C:26]4[CH:39]=[C:22]([F:21])[CH:23]=[CH:24][C:25]=4[CH3:40])=[N:35][CH:34]=3)=[O:37])[CH2:9][CH2:10][C:4]=2[CH:3]=[N:2]1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 155082506-(5-Fluoro-2-methylbenzoyl)aminopyridine-3-carbonyl chlorideHCID 1357270461,4,5,6-Tetrahydropyrazolo[3,4-d]thieno[3,2-b]azepine

Product 1

HCID 19699138HCID 19699138, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2 mmol of 1,4,5,6-tetrahydropyrazolo [3,4-d]thieno[3,2-b]azepine and 10 mmol of triethylamine in 25 ml of dichloromethane is added 4.2 mmol of 6-[(5-fluoro-2-methylbenzoyl)amino]pyridine-3-carbonyl chloride. After stirring overnight, the mixture is worked-up as described for Example 1, and the initial solid treated with 1N NaOH as described for Example 1 to give the product as a solid.

Sources & evidence

ORD record
ord-3b33bcb2c2604eb2b59f4e6881b07007
Source dataset
uspto-grants-1996_07
Patent number
US05532235

Reaction notes

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