Triethylamine → HCID 19699140, compound

HRID 1733999Notes

Reaction equation

HRID 1733999 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([NH2:24])[CH:21]=[CH:20][C:3]=1[C:4]([N:6]1[CH2:12][C:11]2[S:13][CH:14]=[CH:15][C:10]=2[CH2:9][C:8]2[N:16]=[CH:17][CH:18]=[CH:19][C:7]1=2)=[O:5].C(N(CC)CC)C.[F:32][C:33]1[CH:34]=[CH:35][C:36]([CH3:42])=[C:37]([CH:41]=1)[C:38](Cl)=[O:39]>ClCCl>[N:16]1[C:8]2[CH2:9][C:10]3[CH:15]=[CH:14][S:13][C:11]=3[CH2:12][N:6]([C:4]([C:3]3[CH:20]=[CH:21][C:22]([NH:24][C:38](=[O:39])[C:37]4[CH:41]=[C:33]([F:32])[CH:34]=[CH:35][C:36]=4[CH3:42])=[CH:23][C:2]=3[Cl:1])=[O:5])[C:7]=2[CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27373835-Fluoro-2-methylbenzoyl chlorideHCID 19699085HCID 19699085, compound

Product 1

HCID 19699140HCID 19699140, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2 mmol of 5-(2-chloro-4-aminobenzoyl)-6,10-dihydro-5H-pyrido[3,2-b]thieno[3,2-e]azepine and 10 mmol of triethylamine in 25 ml of dichloromethane is added 2.1 mmol of 5-fluoro-2-methylbenzoyl chloride. After stirring at room temperature for 16 hours, the solution is washed with H2O, 1M NaHCO3 and brine. The solution is dried (Na2SO4) and the solvent removed to give the product as a solid.

Workup

  1. washthe solution is washed with H2O, 1M NaHCO3 and brine
  2. dry with materialThe solution is dried (Na2SO4)
  3. customthe solvent removed

Sources & evidence

ORD record
ord-55cd0b7fc0a24fc59c82dfa99734d337
Source dataset
uspto-grants-1996_07
Patent number
US05532235

Reaction notes

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