Cyclopropanecarbonyl chloride → 1,2,3,4-Tetrahydro-1-cyclobutyl-6,7-dimethoxyisoquinoline

HRID 173401Notes

Reaction equation

HRID 173401 reaction equation
[CH:18]1([C:19]([Cl:20])=[O:21])[CH2:22][CH2:23][CH2:24]1.[CH:1]1([CH:4]2[NH:5][CH2:6][CH2:7][c:8]3[cH:9][c:10]([O:16][CH3:17])[c:11]([O:14][CH3:15])[cH:12][c:13]32)[CH2:2][CH2:3]1.[CH:25]1([C:26]([Cl:27])=[O:28])[CH2:29][CH2:30]1>>[CH:1]1([CH:4]2[NH:5][CH2:6][CH2:7][c:8]3[cH:9][c:10]([O:16][CH3:17])[c:11]([O:14][CH3:15])[cH:12][c:13]32)[CH2:3][CH2:2][CH2:18]1

Participants

4

Reactant 3

HCID 77637Cyclopropanecarbonyl chlorideHCID 78705Cyclobutanecarbonyl chlorideHCID 196102151-Cyclopropyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 196102271,2,3,4-Tetrahydro-1-cyclobutyl-6,7-dimethoxyisoquinoline

Sources & evidence

ORD record
ord-bec1e6017e1441d691e0eac72a1837ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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