Hydrochloric Acid → HCID 19439662, compound

HRID 1734013Notes

Reaction equation

HRID 1734013 reaction equation
[ClH:1].C([NH:5][CH2:6][C:7]1[CH:8]=[C:9]([C:13]2[N:14]=[C:15]([N:18]=[C:19]([NH2:21])[NH2:20])[S:16][CH:17]=2)[CH:10]=[CH:11][CH:12]=1)(=O)C>C(O)C>[ClH:1].[ClH:1].[NH2:5][CH2:6][C:7]1[CH:8]=[C:9]([C:13]2[N:14]=[C:15]([N:18]=[C:19]([NH2:21])[NH2:20])[S:16][CH:17]=2)[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10827305HCID 10827305, compound

Product 1

HCID 19439662HCID 19439662, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Conc. hydrochloric acid (10 ml) was added slowly to a suspension of 4-(3-acetylaminomethylphenyl)-2-(diaminomethyleneamino)thiazole (2.8 g) in ethanol (100 ml). The mixture was refluxed for 18 hours. After cooling, the resulting precipitate was collected by filtration to afford 4-(3-aminomethylphenyl)-2-(diaminomethyleneamino)thiazole dihydrochloride (1.75 g).

Workup

  1. temperatureThe mixture was refluxed for 18 hours
  2. temperatureAfter cooling
  3. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-4eb0df48489a49fabd61462c39512ddc
Source dataset
uspto-grants-1996_07
Patent number
US05532258

Reaction notes

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