Benzoyl isothiocyanate → HCID 10692934, compound

HRID 1734014Notes

Reaction equation

HRID 1734014 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[CH:7]=[C:8]([C:12]2[N:13]=[C:14]([NH2:17])[S:15][CH:16]=2)[CH:9]=[CH:10][CH:11]=1)(=[O:3])[CH3:2].[C:18]([N:26]=[C:27]=[S:28])(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CC(C)=O>[C:1]([NH:4][CH2:5][C:6]1[CH:7]=[C:8]([C:12]2[N:13]=[C:14]([NH:17][C:27]([NH:26][C:18](=[O:25])[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[S:28])[S:15][CH:16]=2)[CH:9]=[CH:10][CH:11]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 10562454HCID 10562454, compound

Product 1

HCID 10692934HCID 10692934, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A suspension of 4-(3-acetylaminomethylphenyl)-2-aminothiazole (2.0 g) and benzoyl isothiocyanate (1.32 g) in acetone (40 ml) was refluxed for 5 hours. The resulting precipitate was collected by filtration to afford 4-(3-acetylaminomethylphenyl)-2-(3-benzoyl-2-thioureido)thiazole (2.94 g).

Workup

  1. temperaturewas refluxed for 5 hours
  2. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-d3fb47242fd348a59f21155eabad7ca1
Source dataset
uspto-grants-1996_07
Patent number
US05532258

Reaction notes

Loading…