Methyl iodide → HCID 178504024, compound

HRID 1734015Notes

Reaction equation

HRID 1734015 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[CH:7]=[C:8]([C:12]2[N:13]=[C:14]([NH:17][C:18]([NH2:20])=[S:19])[S:15][CH:16]=2)[CH:9]=[CH:10][CH:11]=1)(=[O:3])[CH3:2].[CH3:21][I:22]>CO>[IH:22].[C:1]([NH:4][CH2:5][C:6]1[CH:7]=[C:8]([C:12]2[N:13]=[C:14]([NH:17][C:18](=[NH:20])[S:19][CH3:21])[S:15][CH:16]=2)[CH:9]=[CH:10][CH:11]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19439666HCID 19439666, compound

Product 1

HCID 178504024HCID 178504024, compoundYield 74.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 4-(3-acetylaminomethylphenyl)-2-thioureidothiazole (5.75 g) and methyl iodide (3.73 g) in methanol (100 ml) was refluxed for 2.5 hours. The solvent was removed under reduced pressure. The residue was crystallized from a mixture of methanol and ethyl acetate to afford 4-(3-acetylaminomethylphenyl)-2-(2-methyl-1-isothioureido)thiazole hydriodide (6.3 g).

Workup

  1. temperaturewas refluxed for 2.5 hours
  2. customThe solvent was removed under reduced pressure
  3. customThe residue was crystallized from a mixture of methanol and ethyl acetate

Sources & evidence

ORD record
ord-8b709d9c826947a5b25a3202dc4505e3
Source dataset
uspto-grants-1996_07
Patent number
US05532258

Reaction notes

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