HCID 70043374, compound → HCID 70044330, compound

HRID 1734098Notes

Reaction equation

HRID 1734098 reaction equation
[ClH:1].C([O:6][C:7]([CH:9]=[CH:10][C:11]1[CH:41]=[CH:40][C:14]([C:15]([NH:17][CH2:18][C:19]2[O:23][C:22]([C:24]([O:26][C:27]3[CH:36]=[CH:35][C:34]4[C:29](=[CH:30][CH:31]=[C:32]([C:37](=[NH:39])[NH2:38])[CH:33]=4)[CH:28]=3)=[O:25])=[CH:21][CH:20]=2)=[O:16])=[CH:13][CH:12]=1)=[O:8])(C)(C)C>C(O)(=O)C>[ClH:1].[C:7]([CH:9]=[CH:10][C:11]1[CH:41]=[CH:40][C:14]([C:15]([NH:17][CH2:18][C:19]2[O:23][C:22]([C:24]([O:26][C:27]3[CH:36]=[CH:35][C:34]4[C:29](=[CH:30][CH:31]=[C:32]([C:37](=[NH:38])[NH2:39])[CH:33]=4)[CH:28]=3)=[O:25])=[CH:21][CH:20]=2)=[O:16])=[CH:13][CH:12]=1)([OH:8])=[O:6]

Participants

3

Reactant 1

HCID 70043374HCID 70043374, compound

Product 1

HCID 70044330HCID 70044330, compoundYield 77.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In 80 ml of acetic acid was dissolved 4 g of 6-amidino-2-naphthyl 5-[4-(2-t-butoxycarbonylvinyl)benzoylaminomethyl]furan-2-carboxylate hydrochloride. Then, hydrogen chloride gas was bubbled into the resulting solution for 1 hour while stirring and cooling with water. The precipitate was collected by filtration and washed with 120 ml of acetone to obtain 2.8 g of the intended product.

Workup

  1. customThen, hydrogen chloride gas was bubbled into the resulting solution for 1 hour
  2. temperaturecooling with water
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with 120 ml of acetone

Sources & evidence

ORD record
ord-16c2460ddbb3405ead6a842c9303d6b3
Source dataset
uspto-grants-1996_07
Patent number
US05532267

Reaction notes

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