反应详情

To 22.3 g of succinic acid, 24.0 g of 6-amidino-2-naphthyl 5-aminomethylfuran-2-carboxylate dihydrochloride and 790 mg of DMAP was added 240 ml of pyridine, and the mixture was stirred while cooling with ice. After 10 minutes, 25.9 g of DCC was added and the mixture was stirred for 3 hours while cooling with ice and then for 16 hours at room temperature. The precipitate was filtered off, and the filtrate was added in small portions into 2 l of ether and stirred at room temperature for 3 hours. After removing the supernatant by decantation, 1 l of acetone was added to the residue and stirred for 3 hours. The precipitate was collected by filtration to obtain 24.0 g of the intended product.

1. temperaturewhile cooling with ice
2. stirringthe mixture was stirred for 3 hours
3. temperaturewhile cooling with ice
4. waitfor 16 hours at room temperature
5. filtrationThe precipitate was filtered off
6. additionthe filtrate was added in small portions into 2 l of ether
7. stirringstirred at room temperature for 3 hours
8. customAfter removing the supernatant by decantation, 1 l of acetone
9. additionwas added to the residue
10. stirringstirred for 3 hours
11. filtrationThe precipitate was collected by filtration