Hydrogen Bromide → HCID 22398840, compound

HRID 1734107Notes

Reaction equation

HRID 1734107 reaction equation
[BrH:1].O.Br.C([O:8][C:9]([CH2:11][CH2:12][C:13]([NH:15][CH2:16][C:17]1[O:21][C:20]([C:22]([O:24][C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[C:30]([C:35](=[NH:37])[NH2:36])[CH:31]=3)[CH:26]=2)=[O:23])=[CH:19][CH:18]=1)=[O:14])=[O:10])(C)(C)C>C(O)(=O)C>[BrH:1].[C:9]([CH2:11][CH2:12][C:13]([NH:15][CH2:16][C:17]1[O:21][C:20]([C:22]([O:24][C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[C:30]([C:35](=[NH:36])[NH2:37])[CH:31]=3)[CH:26]=2)=[O:23])=[CH:19][CH:18]=1)=[O:14])([OH:10])=[O:8]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 22398845HCID 22398845, compound

Product 1

HCID 22398840HCID 22398840, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 250 g of a 30% hydrobromic acid solution in acetic acid was added with water-cooling 8.0 g of 6-amidino-2-naphthyl 5-(3-t-butoxycarbonylpropionylaminomethyl)furan-2-carboxylate hydrobromide, and the mixture was stirred for 3 hours. The precipitate was filtered off, and the filtrate was poured into 2 l of ether. The mixture was stirred for 3 hours at room temperature and the precipitate was collected by filtration to obtain 5 g of the intended product.

Workup

  1. filtrationThe precipitate was filtered off
  2. additionthe filtrate was poured into 2 l of ether
  3. stirringThe mixture was stirred for 3 hours at room temperature
  4. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-9b4fdff4f01c44e08e406ecc5b10cd72
Source dataset
uspto-grants-1996_07
Patent number
US05532267

Reaction notes

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