Aluminum isopropoxide → 6-Amidino-2-naphthyl 5-(3-carboxypropionylaminomethyl)furan-2-carboxylate aluminium hydroxide hydrochloride

HRID 1734108Notes

Reaction equation

HRID 1734108 reaction equation
[ClH:1].[C:2]([CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]1[O:15][C:14]([C:16]([O:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:29](=[NH:31])[NH2:30])[CH:25]=3)[CH:20]=2)=[O:17])=[CH:13][CH:12]=1)=[O:8])([OH:4])=[O:3].CC(C)[O-:34].[Al+3:36].CC(C)[O-:39].CC(C)[O-]>C(O)C.C1(C)C=CC=CC=1>[ClH:1].[OH-:3].[Al+3:36].[C:2]([CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]1[O:15][C:14]([C:16]([O:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:29](=[NH:30])[NH2:31])[CH:25]=3)[CH:20]=2)=[O:17])=[CH:13][CH:12]=1)=[O:8])([OH:4])=[O:3].[OH-:34].[OH-:39]

Participants

5

Reactant 2

HCID 11143Aluminum isopropoxideHCID 22398781HCID 22398781, compound

Product 1

HCID 867496046-Amidino-2-naphthyl 5-(3-carboxypropionylaminomethyl)furan-2-carboxylate aluminium hydroxide hydrochlorideYield 176.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1140TolueneSolvent

Procedure

In 1.84 l of 95% ethanol was dissolved 18.4 g of 6-amidino-2-naphthyl 5-(3-carboxypropionylaminomethyl)furan-2-carboxylate hydrochloride, and a solution of 8.42 g of aluminium isopropoxide in 670 ml of toluene was added dropwise thereto at room temperature. After completion of the addition, the reaction mixture was stirred for 3 hours and allowed to stand overnight. The crystals thus precipitated were collected by filtration to obtain 19.1 g of the intended product.

Workup

  1. customat room temperature
  2. additionAfter completion of the addition
  3. waitto stand overnight
  4. customThe crystals thus precipitated
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-9a593dc58e7c4624b539977688c7818a
Source dataset
uspto-grants-1996_07
Patent number
US05532267

Reaction notes

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