Urea → 5-(Trifluoromethyl)dihydropyrimidine-2,4(1H,3H)-dione
Reaction equation
[NH2:1][C:2]([NH2:4])=[O:3].[F:5][C:6]([F:13])([F:12])[C:7](=[CH2:11])[C:8](O)=[O:9]>C(OC(=O)C)(=O)C>[F:5][C:6]([F:13])([F:12])[CH:7]1[CH2:11][NH:4][C:2](=[O:3])[NH:1][C:8]1=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In 160 ml of acetic anhydride, 13.5 g of urea was suspended and 30 g of trifluoromethacrylic acid was added to the suspension. The resulting mixture was allowed to react at 100° C. for 1 hour and the reaction mixture was concentrated under reduced pressure. The obtained oil was crystallized from 150 ml of water and then recrystallized from 150 ml of water to obtain 25.9 g of 5-trifluoromethyl-5,6-dihydrouracil.
Workup
- customto react at 100° C. for 1 hour
- concentrationthe reaction mixture was concentrated under reduced pressure
- customThe obtained oil was crystallized from 150 ml of water
- customrecrystallized from 150 ml of water
Sources & evidence
- ORD record
- ord-73b879b3502e4edeb3db45e6c5d01aa0
- Source dataset
- uspto-grants-1996_07
- Patent number
- US05532349
Reaction notes
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